The Trauma Pill

January 31st, 2006 | researchmaterial

A “trauma pill” could blot out memories of harrowing events for combat veterans and survivors of accidents or terrorism, say Canadian researchers.

Most memories decay naturally, but people under extreme stress pump an abnormal amount of stress hormones during the event — so the memories are stored differently, said Dr. Alain Brunet, professor of psychiatry at McGill University in Montreal.

“If you have (Post Traumatic Stress Disorder) your memory is so fresh it’s as if the event is happening now,” he said. “For a person to have that vivid flashback certain hormones are released by the brain. If you can block these, the memory is weakened or even removed completely.”

Brunet and colleagues had 20 people suffering from PTSD recall their experiences as vividly as possible in therapy sessions, after being given doses of propranolol — a beta-blocker used to treat high blood pressure, angina and abnormal heart rhythms. Preliminary findings indicate the PTSD sufferers experienced fewer flashbacks and less severe symptoms after taking the drug.

(”Trauma Pill” — pre-fab band name)

15 Responses to “The Trauma Pill”

  1. Sweet. Eternal Sunshine in a pill.

  2. That which does not kill us can now be convienently forgotten.

  3. Presumably this will also be available in some sort of ‘morning after’ version as well. For quickly erasing the sordid results of those accursed beer goggles.

  4. That could be the only reason to thank my PTSD then. Too bad I don’t need those pills, I already have a goldfish memory.

  5. This sounds just like the drug Col. Fury describes in Marvel’s Secret War: Book Five. It’s kind of scary knowing that memories could be wiped out so easily. Heh, if only the “trauma pill” had been invented in the DC universe, certain superheroes could have mind-wiped those villains properly! Take THAT Zatanna!

  6. Propanolol also is also used to treat anxiety…especially its somatic effects (i.e. sweaty palms, queasy stomach, etc.) A side effect is depression comes with long term use. It also induces asthma attacks.

  7. Is this sort of reverse roofies? Someone gets raped, pilled, and wakes up in the morning with a sore ass and no idea why?

    Just wait, you’ll see this in a year being sold in topical format as a lube.

  8. Love me till you drug me baby. Sounds like the newscum have found their soma.

  9. Propranolol is actually a very old drug, and has been generic for a long time. It slows the heart rate by blocking beta-adrenergic receptors which are activated during “fight or flight” responses and is often used in heart patients to control heart rate. It doesn’t really have many side effects other than some people feel a little sleepy, but nothing major, nothing like roofies or whatever, but it does prevent your heart from racing, excess sweating, rapid breathing etc.

    It has been a great tool for a lot of other problems as well, such as performance anxiety, anxiety from air travel, etc. So if you’re a concert pianist and you need your nerves to be rock solid but you can’t take a valium which will make you sleepy and dull, you take a propranolol and your hands don’t shake without any mental side effects. It doesn’t alter your consciousness, so you might still be terrified of the audience and of failure, but since your autonomic nervous system’s fight or flight response is muted, your hands are steady and you don’t piss yourself. This story is really interesting because it suggests if you don’t feel the physical effects of such terrifying experiences, you don’t record them traumatically. It’s not a mind control drug or anything so dramatic, it’s just blocks the physical effects of nervousness and that’s apparently enough to block traumatic memory. Freaking genius really.

  10. Read “On the Sea of Memory: a Journey from Forgetting to Remembering” by Jonathan Cott (an author and Rolling Stone journalist who did the last interview of John Lennon before the killing.) This is a new book that includes all kinds of wild-sounding tales about memory, including this one about beta-blockers and PTS.
    Cott, a wonderful writer, received electroshock treatments for serious depression and subsequently forgot 15 years of his life, 1985 to 2000. In this book he explores memory from all kinds of angles — medical to African storytelling and Tibetan Buddhist remembrance of past lives. In between he writes his own story.
    No, this business with beta-blockers and PTS isn’t a joke and isn’t Brave New World. Traumatic memories, as I understand, never diminish in intensity and so can ruin the lives of people who’ve already been through too much.

  11. So, per Quitter’s information – soldiers could take this drug before a firefight and really kick ass.

  12. Those familiar with the past forty years or medical research originating from McGill University will tell you that it is usually thorough, but at times can be poorly designed, inconsistent, and laced with dramatic pronouncements. As such, it is wise to take such announcements with a dose of scepticism, sleep on it, and then call me in the morning.

  13. The conclusions reached are a little bit much, I agree. It sounds like the researchers are making some extraordinary claims from what is really a simple finding. This isn’t some miracle drug or high tech memory blocker. It’s just a drug that prevents you from feeling the physical side-effects of nervousness and fear. You are still afraid, and you still can be nervous or fearful, you just don’t sweat and your heart doesn’t beat out of your chest. Everyone knows that feeling of terror, your stomach dropping down to your toes, and that impending feeling of doom that makes you shake, sweat and faint. This drug wouldn’t prevent you from feeling afraid, but it would prevent you from experiencing the physical feelings of being afriad.

    Per Bill’s comment, yes, it probably could help soldiers stay calm before a fight, but I think their training and experience is more than adequate and probably safer. If you took beta blockers before a fight you’d be cool as a fish, but in the end they prevent full performance of your body. It might be a bad idea to prevent higher heart rates and autonomic responses in the heat of a battle. But for those who are unused to responding to life-or-death situations or are completely undone by their fear it is a useful drug and based one these researchers’ claims might prevent the long-term storage of traumatic memories.

  14. [...] Warrenellis.com — The Trauma Pill Read “On the Sea of Memory: a Journey from Forgetting to Remembering” by Jonathan Cott (an author and Rolling Stone journalist who did the last interview of John Lennon before the killing.) This is a new book that includes all kinds of wild-sounding tales about memory, including this one about beta-blockers and PTS. Cott, a wonderful writer, received electroshock treatments for serious depression and subsequently forgot 15 years of his life, 1985 to 2000. In this book he explores memory from all kinds of angles — medical to African storytelling and Tibetan Buddhist remembrance of past lives. In between he writes his own story. No, this business with beta-blockers and PTS isn’t a joke and isn’t Brave New World. Traumatic memories, as I understand, never diminish in intensity and so can ruin the lives of people who’ve already been through too much. [...]

  15. I suffered from really bad PTSD. Tried the usual gamut of psychiatric drugs and they messed me up badly. Did research on mind-body interaction, and realised that flash-backs caused my pulse to rise – caused fight-or-flight reactions in an ever-increasing spiral both mental and physical. 3 years ago, researched ways of stopping the cycle. Betablockers stop my pulse from rising, which short-circuits the mind-body onterplay (and in this country they cost about 5% of what psychiatric drugs cost). Took very low doses for about 6 months. Seemed to break the cycle and I am a different person today. In stressful situations, will take a dose to avoid anxiety and have not yet had a serious flashback. Brilliant stuff!!

Coilhouse is Hiring! Apply Here.

Coilhouse - 08 Feb 10

Back around the time of Issue 03, we launched the Small Business Advertising Program to create affordable ad space for indie companies in the print version of Coilhouse. By the time Issue 04 rolled around, the number of advertisers had grown significantly – by this time, we had record labels, jewelry and clothing designers, sculptors, other magazines, web hosts, toy makers and graphic designers advertising in our pages. Click here to see them all. With editorial duties taking up more and more of our time as the weeks go by, the moment has come for us to seek help with the advertising side of running the magazine. We’re looking to hire an Ad Manager for our Small Business Advertising Program, starting with Coilhouse Magazine #05… and possibly subsequent issues.

Full details after the jump!


Read the rest of Coilhouse is Hiring! Apply Here.


Post tags: Coilhouse

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blissblog - 08 Feb 10

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blissblog - 08 Feb 10

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blissblog - 08 Feb 10

State of South Carolina Secretary of State Subversive Agent Form

jwz - 08 Feb 10

Check the appropriate box. Do you or your organization directly or indirectly advocate, advise, teach or practice the duty or necessity of controlling, seizing or overthrowing the government of the United States, the state of South Carolina or any political division thereof?
[ ] YES [ ] NO

If yes, please outline the fundamental beliefs. If applicable, attach a copy of the bylaws or minutes of meetings from the last year.

"Inflection Points" Presentation

Open The Future - 08 Feb 10

For those folks who are interested, here's the Slideshare version of the presentation I gave last week at the Earthquake Engineering Research Institute annual meeting. I was asked to talk about foresight thinking, as the event theme was "The Big One of 2056: What Went Right?" a look at a fictional 7.8 quake in the SF region that was handled as well as they could imagine possible.

My goal was to offer a bit of reassurance to the audience that there is some real utility to thinking about the future, and to spell out (in a cursory way) the kinds of big picture issues they should keep in mind while looking ahead forty-six years.

By and large, it was a successful talk. The post-talk questions were engaged, with little push-back, and I'm told that the overall response from the audience was quite positive.

The talk was video recorded, and I'm told will eventually be available to the public. I'll link when that happens.

CAN GIFTING ECONOMIES SCALE?

John Robb - 08 Feb 10

A gifting economy is different from a barter or market economy in that valuable items are given away to those that need them, without any quid pro quo, exchange, or payment.  Gifting economics (lots of great papers on this topic) were/are the economic heartbeat of hunter-gatherer tribal cultures, the social organization where we spent 99% of our time as homo sapiens sapiens.  Barter was, in contrast, a mechanism for economic interactions between tribes.  

This gifting economic system wasn't based on pure altruism.  It did have an enforcement mechanism to ensure compliance with the system over the longer term.  On the positive side, there was an intangible increase in the social status (using personal or societal metrics) of a tribal member that gifted an item.  On the negative, a failure to offer hospitality or gifts to those in need was considered a mortal slight that could incite violence or expulsion from the tribe.

There were also a considerable number of drivers for gifting at the tribal level.  Here are some:

  • The survival of the tribe, as a group, was more important than the survival of any individual.  However, the loss of any individual could put the tribe at risk.
  • The generation of surplus and innovation was highly uncertain.  Sharing reduced that uncertainty to manageable levels.
  • Sharing reduced internal friction that could put the tribe at risk.

Scalability

It's pretty clear that the societal drivers of tribal gifting economics and the mechanisms of enforcement didn't survive the transition to a global social system composed of billions of members.   Simply, the connections between any two individuals (outside of immediate familial relationships) are too abstract for these drivers and enforcement mechanisms to be relevant.   As a result, market based mechanisms for economic interaction have gained dominance.

However, the ongoing shift of the global market-based economy from a trade in rival goods (tangible items that invoke zero sum economics) to digital non-rival goods (items that can be copied at no expense or diminishment, endlessly) provides a window of opportunity.  It may be possible to revive gifting economics for non-rival goods to amazing beneficial effect.   Some ideas on how this could scale:

  • Automated reputation metrics that enhance social status based on contributions.
  • Mechanisms built using MMO gaming as a way to tie successful gifting to status improvement (leveling) or an ability to attract investment.
  • The creation of an inside/outside barrier that separates a gifting economy from the global economic mainstream.   Automated mutual interdependence (see my friend Bruce Sterling's absolutely brilliant story on this:  "Maneki Neko").

Latest on SNOW

Jean Snow - 08 Feb 10

Latest on SNOW

So what’s the latest on SNOW? I guess two new developments art that I added a dedicated Twitter feed, and also created a Facebook fan page. The Twitter feed is mostly just automated with new articles from the site — because some people actually prefer that over RSS feeds these days — but I do keep an eye on it, and will reply to questions and comments. The Facebook page is just another way of putting the site out there, and should be a good way of informing members of SNOW-related events as they happen.

Regular content updates have also continued over the past week, with a few new guest columns and my regular news items. Here’s a list of what you may have missed over the past few days.

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blissblog - 08 Feb 10

I Know It?s Over?

Kieron Gillen - 08 Feb 10